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相關文獻:

芝麻素改善肝臟機制的相關文獻:

 Anni Nutr Metab 1993;37(4):218-224
Protective effects of sesamin again liver damage caused by alcohol or carbon tetrachloride in rodents..
Akimoto K, Kitagawa Y, Akamatsu T, Hirose N, Sugano M, Shimizu S, Yamada H.
Institute for Biomedical Research Suntory Ltd., Osaka, Japan.
芝麻素對老鼠之酒精和四氯化碳所造成之肝臟損傷具有保護的作用。

J. Pharm. Pharmacol 2000;52:11638-1169
Antioxidant Lignans from Machilus thunbergii Protect carbon tetrachloride-injured Primaary Cultures of Rat Hepatocytes..
YOUNG Y. Y., SO YOUNG KANG, HAE YOUNG PARK, SANG HYUN SUNG, EUN JU LEE, SUN YEOU KIM AND YOUNG CHOONG KIM
Seoul,Korea
老鼠的肝細胞在加入抗氧化之芝麻木酚素後,可保護其避免四氯化碳之毒害。

(B) Studies suggesting that sesamin is able to protect live and improve liver function.
研究顯示芝麻素可以「保護肝臟及改善肝功能」。

Hsu DZ,Li YH,Chien SP,Liu MY:Effects of sesamin oil on oxidative stress and hepatic injury after cecal ligation and puncture in rats.Shock 21:466-469,2004
芝麻對於盲腸穿刺結紮後的老鼠的肝臟損傷之抗氧化作用

Preventive effects of Sesame lignans on Fatty liver induced by Alcohol.
日本家政學會誌1999 vol.50,No.8:807-812
芝麻木酚素對阻止酒精性脂肪肝發生之效果

Yoshinobu K.:Antioxidative roles of Sesamin, a functional lignan in sesame seed, and it’s effect on lipid-and alcohol-metabolism in the liver:A DNA microarray study.BioFactors 2004 vol.21 No.1-4:191-196
芝麻木酚素強化肝藏對酒精及脂質的代謝之工功能

芝麻素於抗高血壓的相關文獻:

D.Nakano,et al; Vascular Disease Prevention,vol.1,No.3,Nov.2004,:233-241(9)
Antihypertensive Effect of Sesamin.

芝麻素之抗高血壓的作用

Atherosclerosis. 1996.122135-136
日本 Suntory 山得利 、 日本大阪藥科大學

芝麻素具有可以降低高血壓之功能 

Biol Pharm Bull 1998 May;21(5):469-73
Antihypertensive effect of sesamin. Ⅲ. Protection against development and maintenance of hypertension in stroke-prone spontaneously hypertensive rats.
Matsumura Y, Kita S, Tanida Y, Taguchi Y, Morimoto S, Akimoto K, Yanaka T Department of Pharmacology. Osaka University of Pharmaceutical Sciences. Takatsuki, Japan.

芝麻素之抗高血壓的作用.III.對自發性易中風老鼠之高血壓的發展及持續之抑制作用。

 Biod Pharm Bull 1995 Sep;18(9):1283-5
Antihypertensive effect of sesamin. Ⅱ Protection against two-kidey, on-clip renal hypertension and cardiovascular hypertrophy.
Kita S, Matsumura Y, Morimoto S, Akimoto K, furuya M, Oka N, Tanaka T Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.

芝麻之抗高血壓的作用.Ⅱ.保護及避免腎臟高血壓及心臟肥大。

Biol Pharm Bull 1995 Jul;18(7):1016-9
Antihypertensive effect of sesamin.Ⅰ. Protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy.
Matsumura Y, Kita S, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Osaka, Japan.

芝麻素之抗高血壓的作用..對deoxycoritcosterone acetate-salt誘導之高血壓及心臟肥大之阻止作用。

Journal of Pharmacology and Experimental Therapeutics 318:328-335,2006.
Sesamin Metabolites Induce an Endothelial Nitric Oxide-Dependent Vasorelaxation through Their Antioxidative Property-Independent Mechanisms:Possible Involvement of the Metabolites in the antihypertensive Effect of Sesamin

芝麻素抗高血壓功能之作用機轉
日本大阪藥科大學

芝麻素於降膽固醇的相關文獻:

J Lipid Res 1991 Apr;32(4):629-38
Inhibition of cholesterol absorption and synthesis in rats by sesamin.
Hirose N, Inolle T, Nishitlara k, Sugano M, AKimoto k, Shimizu S, Yamada H Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.
芝麻素可以抑制老鼠膽固醇之吸收和合成。

Clin Exp Pharmacol Physiol 1995 Dec;22 Suppl 1:S310-2
Sesame lignans modulate cholesterol metabolism in the stroke-prone spontaneously hypertensive rat. Ogawa H, Sasagawa S, Murakami T, Yoshizumi H Department of Hygiene, Kinki University School of Medicine, Japan.

芝麻素可以調節易中風老鼠之膽固醇的代謝

Atherosclerosis 1996 Apr 26;122(1):135-36
Hypocholesterolemic effect of sesame lignan in humans.TIirata F,Fqjita k,IshiKura Y,Hosoda k, IshikawaT,Nakamura H
芝麻木酚素對人類的高固醇症之影響。

Int. J Vitam Nutr Res 1995;65(3):162-8
alpha-Tocopherol enhances the hypocholesterolemic action of sesamirIin rats. Nakabayashi A, Kitagawa Y, Suwa Y, AKimoto k, Asami S, Shimizu S, Hirose N, Sugano M, Yamada H Institute for Biomedical Research, Suntory Ltd., Osaka, Japan.

α-Tocopherol
會加強芝麻素對老鼠高膽固醇症之抑制作用

Rolis C.W.Hou,H.M.Huang,Jason T.C.Tzen,:Protective Effects of Sesamin and Sesamolin on
Hypoxic Neuronal and PC12 Cells.;J.of Neuroscience Res.2003.,74:123-133
芝麻素與芝麻醇素具有保護神經與類神經細胞之功能
(在模擬中風情況下,芝麻素能降低神經細胞之傷害)

Rolis C.W.Hou,et al.,Protecive effects of sesamin and sesamolin on murine BV-2 microglia cell line under Hypoxia.:Neuroscience Letters 367(2004):10-13
芝麻素及芝麻醇素用於預防中風及保護神經退化之用途

芝麻素於抗癌的相關文獻:

Olsen, K.E.B. Knudsen, B.L. Thomsen, S. Loft,..et al. 2004,Plasma Enterolactone and Breast Cancer Incidence by Estrogen Receptor Status. Cancer Epidemiology Biomarkers& Prevention Vol.13, 2084-2089.
研究顯示木質酚素(Lignans)有助於預防乳癌
 

Anticancer Res 1992 Jul-Aug;12(4):1259-65
Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis.
Hirose N, Doi F, Ueki T, Akanwa k, Chijiiwa K, Sugano M, AKimoto K, Shinimizu S,Yamada H Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.
芝麻素對利用7,12-dimethylbenz[a]-anthracene 誘發之老鼠的乳癌具有抑制作用。


Journal of Cancer Prevention Vol. 15, pp. 225-232.
女性攝取高含量木酚素來保持血漿中「腸內二酯(enterolactone)」的量可降低乳癌危險率達78%

Jansen GH, Arts IC, Nielen MW, Muller M;..et; Uptake and Metabolism of enterolactone and enterodiol by human colon epithelial cells. 2005;Arch Biochem Biophys;435(1):74-82
木質酚有助於預防結腸直腸癌的作用機轉探討

 Penalvo, J. L., Heinonen S-M, Aura, A-M and Adlercreutz, H, 2005, Dietary
Sesamin is converted to enterolactone in humans. The Journal of  Nutrition.
135(5):1056~1062

膳食的芝麻素於人體內會轉變成為腸內二酯
由實驗室及臨床的證據皆已顯示在血漿及尿液中之高的腸內二酯濃度與罹患某些慢性病(例如:癌症及冠狀動脈心臟病)有負的相關性

Kansai window,2003, Sesamin Found Effective to protect Skin from UV- ray,
Kippo News,vol.10,no.424,Wednesday,April 30.
芝麻素被發現可有效保護皮膚避免紫外線之傷害

其他相關文獻:

Lipids 1995 Nov;30(11):1019-28
Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet.
Yamashita k, Iizuka Y, Imai T, Namiki M Department of Food and Nutrition, School of Lit Studies, SugiYama Jogakuen University, Nagoya, Japan.
芝麻種子和其木質酚素會對餵飼低量維生素E之老鼠會產生明顯的加強其維生素 E活性的作用。

Lipids 1995 Jun;30(6):499-505
Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. kamal-Eidin A, Pettersson D, Appelqvist LA
Department of Food Science, Swedish University of Agricultural Sciences, Uppsala.
芝麻素(來自芝麻油的成份)可增加餵飼老鼠後之維生素E的吸收量。

Biofactors 2000;11(1-2):11-3
Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet.
Yamashita k, Kagaya M, Higuti N, Kiso Y Department of Food and Nutrition, Sugiyama Jogakuen University, Nagoya, Japan.
芝麻素和維生素對餵飼高22碳六烯酸飲食的老鼠之脂肪過氧化具有加乘作用

 

 

 

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